Project description The grant will enable us to establish a scientific community with the potential to build bridges between several disciplines and expertise in epigenetics, physiology, chromatin structure, metabolism, comparative biology and bioinformatics. We hope to develop innovative strategies to improve the metabolic health of the coming generations by making recommendations related to lifestyle. Read more
Project description We will use experimental and computer-based techniques to obtain a whole new understanding based on systems biology of how fat cells receive and respond to cellular signals. The goal is to understand how this signalling function varies with sex, genetic factors and the specific fat deposits and how changes in these signalling functions as obesity develops contribute to the pathophysiological effects of obesity. Read more
Project description Our goal is to discover drugs for effective and safe inhibition of metabolic microRNAs and assess their therapeutic potential to treat NASH in highly relevant preclinical models of NASH. Furthermore, we will evaluate hepatic and circulating microRNAs in human samples as biomarkers for NASH. We believe that successful development of combined diagnostics and microRNA-targeted therapeutics has the potential to guide new treatment options for patients with NASH. Read more
Project description The project gathers internationally leading experts on intrinsically disordered proteins across a wide range of fields. They have the complementary expertise, scientific experience, flexibility and impact to create a conceptual basis for transforming protein chemistry and all related disciplines, including the health and medical sciences. Read more
Project description Our genetic material, the genome, produces RNA that forms either proteins or independent RNA molecules. However, genomic DNA is hyperactive, and only a fraction of the RNA produced ends up being functional molecules. The rest degrade. Which molecular machines detect and remove inappropriate RNA so that the cells do not drown in their own molecular waste? This is the question that the Exo-Adapt research centre will focus on for the next 6 years. Read more
Project description
The researchers will integrate computer-based biophysics, high-throughput protein chemistry and genome analysis to understand how changes in the genome affect protein biology and how this knowledge can be used to diagnose and ultimately treat people with diseases. Read more
Clive Sabel, Professor, Department of Environmental Science, Aarhus University
Project description: Exposure to many environmental factors is damaging our health, but is illness a result of individual cases of high-risk exposure that can damage health or the result of slow accumulation throughout life? Read more
Morten Sommer, Professor, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark
Project description: Bacteria are naturally present in the human body and affect our health both positively and negatively. Despite their potential roles as targets for treating various diseases, manufacturing targeted medicine is still a major challenge. Read more
Søren Brunak, Professor, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
Project description: The project uses big data thinking to study all diseases at once, and especially in which order hundreds of diseases occur in a lifelong perspective. This includes large quantities of data from healthy individuals, such as from blood donors in Denmark and abroad who have consented to their data being analysed. Read more
Kurt Gothelf, Professor, Department of Chemistry, Aarhus University
Project description: Most drugs used today have only one activation mechanism, and manufacturing drugs with several functions is both difficult and expensive. The aim of the project is to carry out research on new drugs with several activation mechanisms. Read more
Rudi Westendorp, Professor, Department of Public Health, University of Copenhagen
Project description: The continuous increase in life expectancy and the numbers of years we spend with illness cause profound upheaval to all of us. Age is the most important risk factor for most chronic disorders, including diabetes, cancer and dementia, but it is not well understood why that is so. Read more
Dimitrios Stamou, Professor, Department of Chemistry, University of Copenhagen
Project description: Life on our planet emerged through the evolution of cells endowed with the ability to metabolize energy, grow, adapt and ultimately reproduce. Cells are composed of molecules positioned in complex arrangements that are critically important for life. Read more
Thomas Lars Andresen, Professor, Department of Micro- and Nanotechnology, Technical University of Denmark
Project: Insulin is a medicine that can only currently be administered by using syringes and needles. Injecting insulin causes great discomfort for many people, creates a risk of infection and often requires trained health personnel, which is expensive for society. Read more
Hanne Mørck Nielsen, Professor, Department of Pharmacy, University of Copenhagen, Denmark
Project: Many life-threatening diseases are controlled effectively by injecting peptide- and protein-based drugs known as biopharmaceuticals. Read more
Tilmann Weber, Senior Researcher, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark
Project: Antibiotic resistance is increasing, and new antibiotics are desperately needed to combat infections. The project group will use innovative screening technologies to identify new potential antibiotics and the genes that code for their biosynthesis. Read more
Peter Eigil Nielsen, Professor, Department of Cellular and Molecular Medicine, University of Copenhagen
Project: This project will use new strategies to develop specific antibiotics to combat the serious and growing threat to health arising from infections caused by multidrug-resistant bacteria. Read more
Frank Møller Aarestrup, Professor, National Food Institute, Technical University of Denmark
Project: Effectively reducing the prevalence of antibiotic resistance and using the best antibiotics requires knowledge based on continually monitoring the prevalence and spread of different types of antibiotic resistance globally. Read more
Torben Hansen, Professor, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark
Project: The portal vein transports metabolites produced by the human gut microbiota directly to the liver, and these may play a role in developing several liver diseases. Read more
Fredrik Bäckhed, Professor, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark and Wallenberg Laboratory for Cardiovascular and Metabolic Research, Sahlgrenska Academy, University of Gothenburg, Sweden
Project: Evidence indicates that the bacterial flora in the human gastrointestinal tract substantially influences metabolism and development of cardiometabolic diseases. Nevertheless…. Read more
Julen Zeirath, Professor and Scientific Director, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen; and Karolinska Institutet, Stockholm, Sweden
Project description: Physical activity has a documented positive effect in preventing and treating type 2 diabetes. But does it make a difference when we exercise? This is one question international collaboration will address by examining the extent to which and how the body’s circadian rhythm influences the ability of muscles to take up and metabolize sugar from the blood and the effects of exercise in relation to type 2 diabetes. Read More
Peter Rossing, Senior Principal Investigator and Head of Complications Research, Steno Diabetes Center
Project description: Diabetes is often associated with impaired kidney function, a complication that can develop into kidney failure. No effective treatment has been discovered so far. The project proposes international collaboration on state-of-the-art screening of many biological markers in blood, urine and gut flora taken from patients with impaired kidney function. Read more
Thue W. Schwartz, Professor and Scientific Director, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
Project description: The body’s metabolism is regulated somewhat by hormones produced by cells located in the gut wall that detect both the nutrients present in the gut and components that circulate in the blood. Read more
Troels Staehelin Jensen Clinical Professor, Department of Clinical Medicine, Aarhus University
Project description: Diseases of the nervous system that result in pain symptoms, nerve damage, numbness and often amputation comprise some of the most significant personal and economic complications associated with diabetes. Read more
