Dimitrios Stamou, Professor, Department of Chemistry, University of Copenhagen
Jay T. Groves, Professor, College of Chemistry, University of California, Berkeley, United States
Orion Weiner, Professor, Cardiovascular Research Institute, School of Medicine, University of California, San Francisco, United States
Center for Geometrically Engineered Cellular Systems
Life on our planet emerged through the evolution of cells endowed with the ability to metabolize energy, grow, adapt and ultimately reproduce. Cells are composed of molecules positioned in complex arrangements that are critically important for life. Here we propose to engineer these geometrical arrangements, using novel nanotechnologies and optogenetic methods, in order to achieve new levels of synthetic control over the behaviour and function of molecular systems and living cells. Our work will focus on geometrical engineering of 1) T-cells for cancer immunotherapy and 2) the most common target of all drugs in the market today (G protein coupled receptors).