Fredrik Bäckhed, Professor, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark and Wallenberg Laboratory for Cardiovascular and Metabolic Research, Sahlgrenska Academy, University of Gothenburg, Sweden
Gut microbiome effects on cardiometabolic disease through metabolism-modifying metabolites (Gut-MMM)
Evidence indicates that the bacterial flora in the human gastrointestinal tract substantially influences metabolism and development of cardiometabolic diseases. Nevertheless, the extent to which these factors are linked and whether pharmaceuticals can be developed on this basis are currently unclear. The underlying hypothesis of the project is that microbially synthesized molecules do not simply play a role as the body’s energy metabolizers and building blocks; they also play an important role as signal molecules that interact with receptors in endocrine organs.