Many life-threatening diseases are controlled effectively by injecting peptide- and protein-based drugs known as biopharmaceuticals. Administering these drugs as tablets would be very advantageous, especially for people with chronic diseases and those who need to take the medicine frequently. However, the challenge is that these drugs are broken down in the intestines, and the amount absorbed by the intestines varies tremendously. Delivering the drugs throughout the body following oral administration is therefore enormously challenging, and there are still no general methods for solving this problem.
“The project focuses on solving the challenges of drug delivery by developing a better and more detailed understanding of how peptide- and protein-based drugs integrate with and are transported across the intestinal membrane and arrive at their target areas. To move towards achieving this ambitious target, the project will develop new unique drug-delivery concepts, technologies and methods. This major project involves advanced chemistry, nanorobots and visualizing the transport of drugs in the body. This will enable us to design and study systems for oral drug delivery of biopharmaceuticals,” says Hanne Mørck Nielsen.
Hanne Mørck Nielsen, Professor, Department of Pharmacy, University of Copenhagen, Denmark
Knud J. Jensen, Professor, Department of Chemistry, University of Copenhagen, Denmark
Jesper Glückstad, Professor, Department of Photonics Engineering, Technical University of Denmark
Urs O. Häfeli, Professor, Faculty of Pharmaceutical Sciences, University of British Columbia, Canada; and Department of Pharmacy, University of Copenhagen, Denmark