Helle Krogh Johansen, Professor, Department of Clinical Microbiology, University Hospital of Copenhagen, Denmark
Persistent bacterial infections (PERFECTION)
Manuel Amieva, Professor, Department of Pediatrics – Division of Infectious Diseases, Stanford University, USA
Thomas Bjarnsholt, Professor, Costerton Biofilm Centre, University of Copenhagen, Denmark
Kim Bak Jensen, Associate Professor, Biotech Research & Innovation Centre, University of Copenhagen, Denmark
Bacterial infections, that persist despite the use of antibiotic therapy, constitute a serious and growing health care problem. In our project we will address the following questions: why do some infections persist, can markers for persistent infections be identified, and can treatment be improved? Three types of persistent infections will be investigated: gastric ulcers, airway infections and wounds. For the bacterial infection studies, we will use newly developed epithelial spheroids, which are able to self-organise into miniature organs and also biofilm models which both mimic as much as possible the relevant human condition. In these models’ persistent infections can be studied and treated in ‘almost’ natural environments. We expect to get important insight about early bacterial persistence mechanisms and how bacteria escape therapy. This knowledge will be groundbreaking in development of diagnostic tools and for detection of persistence markers and treatment.