Saturday, 22 December 2018

Grant recipient
Sakari Kauppinen, Professor, Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, Denmark

Project title
Therapeutic Targeting of Metabolic MicroRNAs as a New Treatment Paradigm for NASH

Co-applicants
Anders Näär, Professor, Department of Nutritional Sciences & Toxicology, University of California, Berkeley, USA

Pier Paolo Pandolfi, Professor, the Cancer Center and Institute for RNA Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

Ryan Temel, Associate Professor, Saha Cardiovascular Research Center, Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, USA

Brief description
Our goal is to discover drugs for effective and safe inhibition of metabolic microRNAs and assess their therapeutic potential to treat NASH in highly relevant preclinical models of NASH. Furthermore, we will evaluate hepatic and circulating microRNAs in human samples as biomarkers for NASH. We believe that successful development of combined diagnostics and microRNA-targeted therapeutics has the potential to guide new treatment options for patients with NASH.