Susanne Mandrup, Professor, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense
ADIPOSIGN – Center for Adipocyte Signaling
Jan-Wilhelm Kornfeld, Professor, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense
Madan Babu, Research Director, Regulatory Genomics and Systems Biology Group, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
Zachary Gerhart-Hines, Associate Professor, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark
We will use experimental and computer-based techniques to obtain a whole new understanding based on systems biology of how fat cells receive and respond to cellular signals. The goal is to understand how this signalling function varies with sex, genetic factors and the specific fat deposits and how changes in these signalling functions as obesity develops contribute to the pathophysiological effects of obesity.